4-Thiazolidinecarboxylic acid, methyl ester → Methyl 3-(((Ethoxy(propylthio)phosphinyl)amino)carbonyl)-4-thiazolidinecarboxylat

HRID 1461230

反応式

HRID 1461230 の反応式
[S:1]1[CH2:5][CH:4]([C:6]([O:8][CH3:9])=[O:7])[NH:3][CH2:2]1.[P:10](=[O:21])([N:18]=[C:19]=[O:20])([S:14][CH2:15][CH2:16][CH3:17])[O:11][CH2:12][CH3:13]>CCOCC>[CH2:12]([O:11][P:10]([NH:18][C:19]([N:3]1[CH:4]([C:6]([O:8][CH3:9])=[O:7])[CH2:5][S:1][CH2:2]1)=[O:20])([S:14][CH2:15][CH2:16][CH3:17])=[O:21])[CH3:13]

参加物

4

反応物 2

HCID 933294-Thiazolidinecarboxylic acid, methyl esterHCID 19873995O-ethyl S-propyl phosphoroisocyanatidothioate

生成物 1

HCID 19980199Methyl 3-(((Ethoxy(propylthio)phosphinyl)amino)carbonyl)-4-thiazolidinecarboxylat

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒

実験手順

To a solution of 2.2 g of methyl thiazolidine-4-carboxylate in 50 ml of ether was added dropwise with stirring at ambient temperature 3.14 g of O-ethyl S-propyl phosphoroisocyanatidothioate. The mixture was allowed to react overnight at ambient temperature and was then concentrated by evaporation under reduced pressure to obtain 5.2 (97 percent of theory) of the title compound as a colorless oil having a refractive index at 25° C. of 1.5312.

後処理

  1. customto react overnight at ambient temperature
  2. concentrationwas then concentrated by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-127e2becfb8343319dcb09eeeb9d3311
出典データセット
uspto-grants-1991_12
特許番号
US05075293

関連ノート

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