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Potassium Carbonate → 6-Hydroxymethyl-5-p-methoxybenzyloxy-2-methyl-1-diphenylmethyloxy-4-pyridone

HRID 1461245
ノート
印刷プレビュー

反応式

HRID 1461245 の反応式
[OH:1][CH2:2][C:3]1[N:8]([OH:9])[C:7]([CH3:10])=[CH:6][C:5](=[O:11])[C:4]=1[O:12][CH2:13][C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+].[C:28]1([CH:34](Br)[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>CN(C)C=O>[OH:1][CH2:2][C:3]1[N:8]([O:9][CH:34]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)[C:7]([CH3:10])=[CH:6][C:5](=[O:11])[C:4]=1[O:12][CH2:13][C:14]1[CH:15]=[CH:16][C:17]([O:20][CH3:21])=[CH:18][CH:19]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 236603BromodiphenylmethaneHCID 146529276-Hydroxymethyl-5-p-methoxybenzyloxy-2-methyl-1-hydroxy-4-pyridone

生成物 1

HCID 146529286-Hydroxymethyl-5-p-methoxybenzyloxy-2-methyl-1-diphenylmethyloxy-4-pyridone

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

To a solution of 300 mg of 6-hydroxymethyl-5-p-methoxybenzyloxy-2-methyl-1-hydroxy-4-pyridone in 10 ml of dimethylformamide were successively added 213 mg of potassium carbonate and 423 mg of diphenylmethyl bromide. The mixture was stirred at room temperature for 2 hours. After completion of the reaction, the reaction liquid was concentrated and the concentrate was added to 20 ml of water and 40 ml of dichloromethane. The organic phase was washed with 20 ml of water.

後処理

  1. customAfter completion of the reaction
  2. customthe reaction liquid
  3. concentrationwas concentrated
  4. additionthe concentrate was added to 20 ml of water and 40 ml of dichloromethane
  5. washThe organic phase was washed with 20 ml of water

出典と根拠

ORDレコード
ord-5f0806a6cd8d4a3aad7a6640a3faf1d2
出典データセット
uspto-grants-1991_12
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05075299

反応ノート

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