Ethylenediamine → HCID 10104585、化合物

反応式

[CH3:1][N:2]([CH2:4][C:5]1[O:9][C:8]([C:10]([O:12]CC)=O)=[CH:7][CH:6]=1)[CH3:3].[CH2:15]([NH2:18])[CH2:16][NH2:17]>>[CH3:3][N:2]([CH2:4][C:5]1[O:9][C:8]([C:10]([NH:17][CH2:16][CH2:15][NH2:18])=[O:12])=[CH:7][CH:6]=1)[CH3:1]

参加物

反応物 2

HCID 3301Ethylenediamine

HCID 100355992-Furancarboxylic acid, 5-[(dimethylamino)methyl]-, ethyl ester

生成物 1

HCID 10104585HCID 10104585、化合物収率 104.6%

反応条件

温度: 80 °C

実験手順

A mixture consisting of 49.0 g (248 mmol) of ethyl 5-(dimethylaminomethyl)-2-furancarboxylate and 150 g (2.496 mol) of anhydrous ethylenediamine was heated at 80° C. for 2 hours. After cooling, the excess ethylenediamine was distilled off under reduced pressure to give 54.8 g (98.0%) of 5-(dimethylaminomethyl)-N-(2-aminoethyl)-2-furancarboxamide (Compound a) as light yellow oil.

後処理

temperatureAfter cooling
distillationthe excess ethylenediamine was distilled off under reduced pressure

出典と根拠

ORDレコード: ord-e14d357ae5d74a0fabda7030b1bbb5c5
出典データセット: uspto-grants-1991_12
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05075301

反応ノート

読み込み中…

参加物