HCID 15675385、化合物 → 1-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole

HRID 1461270ノート

反応式

HRID 1461270 の反応式
[N:1]([CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7]1=[O:15])=[N+]=[N-].[H][H]>C(O)C.O.[C].[Pd]>[NH2:1][CH2:4][CH2:5][N:6]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7]1=[O:15]

参加物

6

反応物 2

HCID 15675385HCID 15675385、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 117451761-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole収率 89.1%

試薬・触媒・溶媒 3

HCID 178418390HCID 178418390、化合物触媒HCID 702Ethanol溶媒HCID 962Water溶媒

実験手順

In 150 ml of ethanol was dissolved 1.3 g (6.4 mmol) of Compound i followed by addition of a suspension of 65 mg (5 w/w%) of 10% palladium-carbon in 2 ml of water. The mixture was stirred at room temperature for 4.5 hours, with hydrogen gas being bubbled into the mixture. The reaction mixture was then filtered and the filtrate was concentrated to give 1.01 g (89.1%) of 1-(2-aminoethyl)-2,3-dihydro-2-oxo-1H-benzimidazole (Compound j) as white crystals.

後処理

  1. custombeing bubbled into the mixture
  2. filtrationThe reaction mixture was then filtered
  3. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-74fff30f668c4f55893006e613832f27
出典データセット
uspto-grants-1991_12
特許番号
US05075301

反応ノート

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