4-Methyl-5,6-dihydroquinoline → 5,6,7,8-tetrahydro-7-(N-hydroxy-1-propylamino)-4-methylquinoline

HRID 1461284ノート

反応式

HRID 1461284 の反応式
[CH3:1][C:2]1[C:11]2[CH2:10][CH2:9][CH:8]=[CH:7][C:6]=2[N:5]=[CH:4][CH:3]=1.Cl.[CH2:13]([NH:16][OH:17])[CH2:14][CH3:15]>CO>[OH:17][N:16]([CH2:13][CH2:14][CH3:15])[CH:8]1[CH2:7][C:6]2[N:5]=[CH:4][CH:3]=[C:2]([CH3:1])[C:11]=2[CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 121336204-Methyl-5,6-dihydroquinolineHCID 12355438N-propylhydroxylamine hydrochloride

生成物 1

HCID 148359505,6,7,8-tetrahydro-7-(N-hydroxy-1-propylamino)-4-methylquinoline収率 73.4%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

This compound was prepared from the product of Step 6 (4.5 g, 30 mmol), 1-propylhydroxylamine hydrochloride (6 g, 55 mmol), and methanol (20 ml) by the method outlined in Example 10. The crude material was recrystallised from cyclohexane to give the product (4.85 g).

後処理

  1. customThe crude material was recrystallised from cyclohexane

出典と根拠

ORDレコード
ord-12d23821971b471a86277c7366c7d985
出典データセット
uspto-grants-1991_12
特許番号
US05075303

反応ノート

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