2,3-Dichlorobenzaldehyde → HCID 15035858、化合物

HRID 1461474ノート

反応式

HRID 1461474 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:14][C:13](=O)[CH2:12][S:11](=[O:17])(=[O:16])[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:18][C:19]1[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:20]=1[CH:21]=O.[NH2:28]/[C:29](/[CH3:36])=[CH:30]\[C:31]([O:33][CH2:34][CH3:35])=[O:32]>C(O)C>[Cl:18][C:19]1[C:26]([Cl:27])=[CH:25][CH:24]=[CH:23][C:20]=1[CH:21]1[C:12]2[S:11](=[O:17])(=[O:16])[CH2:10][CH2:9][N:8]([C:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])=[O:7])[CH2:14][C:13]=2[NH:28][C:29]([CH3:36])=[C:30]1[C:31]([O:33][CH2:34][CH3:35])=[O:32]

参加物

5

反応物 3

HCID 357452,3-DichlorobenzaldehydeHCID 6437562-Butenoic acid, 3-amino-, ethyl ester, (2Z)-HCID 19980844tert-Butyl 6-oxo-1,4-thiazepane-4-carboxylate 1,1-dioxide

生成物 1

HCID 15035858HCID 15035858、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 4-N-(t-butyloxycarbonyl)-1,1-dioxo -2,3,4,5,6,7-hexahydro-1,4-thiazepin-6-one (2.00 g, 7.60 mmole) from Example 6, 2,3-dichlorobenzaldehyde (1.33 g, 7.60 mmole) and ethyl 3-aminocrotonate (0.98 g, 7.60 mmole) was heated to reflux in 40 mL of ethanol for 24 hours. The ethanol was removed under reduced pressure and replaced with 85 mL of toluene. The mixture was heated to reflux for 2 hours, cooled to room temperature and filtered to obtain the produce (2.45 g, 61%).

後処理

  1. temperaturewas heated
  2. customThe ethanol was removed under reduced pressure
  3. temperatureThe mixture was heated
  4. temperatureto reflux for 2 hours
  5. filtrationfiltered
  6. customto obtain the
  7. customproduce (2.45 g, 61%)

出典と根拠

ORDレコード
ord-06de9772ec26415da65775a0f59258d3
出典データセット
uspto-grants-1991_12
特許番号
US05075440

反応ノート

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