Acetyl chloride → 2-(Acetyloxy)-4-(methylsulfanyl)butanoic acid
反応式
[OH:1][CH:2]([CH2:6][CH2:7][S:8][CH3:9])[C:3]([O-:5])=[O:4].[Ca+2].[OH:11][CH:12](CCSC)[C:13]([O-])=O.C(Cl)(=O)C>>[C:12]([O:1][CH:2]([CH2:6][CH2:7][S:8][CH3:9])[C:3]([OH:5])=[O:4])(=[O:11])[CH3:13]参加物
3
実験手順
Calcium 2-hydroxy-4-(methylthio)butyrate (33.8 g, 0.1 g-mole) and acetyl chloride (110 g) are refluxed in a 250 ml round-bottom flask for 2.5 hours. The mixture is evaporated to a syrup and treated with 150 ml acetone. The brown mixture is stirred for 30 minutes, filtered, and the filtrate evaporated to dryness to give 37 g, 96.4% of brown viscous oil which is identified by TLC and nmr.
後処理
- customThe mixture is evaporated to a syrup
- additiontreated with 150 ml acetone
- filtrationfiltered
- customthe filtrate evaporated to dryness
出典と根拠
- ORDレコード
- ord-8174378126114fb7810c69dbc4a7ccd9
- 出典データセット
- uspto-grants-1991_12
- 特許番号
- US05075502
反応ノート
読み込み中…