1(2H)-Phthalazinone → HCID 19979310、化合物

HRID 1461746ノート

反応式

HRID 1461746 の反応式
[OH-].[K+].[O:3]=[C:4]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH:7]=[N:6][NH:5]1.Br[CH2:15][CH2:16][O:17][CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][O:19]1>O.CS(C)=O>[O:19]1[CH2:20][CH2:21][CH2:22][CH2:23][CH:18]1[O:17][CH2:16][CH2:15][N:5]1[N:6]=[CH:7][C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[C:4]1=[O:3]

参加物

6

反応物 3

HCID 83941(2H)-PhthalazinoneHCID 14797Potassium HydroxideHCID 866212-(2-Bromoethoxy)tetrahydro-2H-pyran

生成物 1

HCID 19979310HCID 19979310、化合物

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

実験手順

A solution of 41.5 g of potassium hydroxide in 53 ml of water is added at room temperature to a solution of 61 g of 1-oxophthalazine in 430 ml of dimethyl sulfoxide. After 30 minutes, 130 g of tetrahydro-2-pyranyl 2-bromoethyl ether are added to the suspension obtained. The mixture is left stirring for 30 hours at room temperature and then concentrated, the residue is taken up in 400 ml of water and the product is extracted with dichloromethane. The organic phase is concentrated.

後処理

  1. customobtained
  2. waitThe mixture is left
  3. concentrationconcentrated
  4. extractionthe product is extracted with dichloromethane
  5. concentrationThe organic phase is concentrated

出典と根拠

ORDレコード
ord-725db703735c4a669a505d486e532aa0
出典データセット
uspto-grants-1991_12
特許番号
US05077288

反応ノート

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