Benzonitrile, 4-bromo- → 4-(8-Hydroxy-1,4-dioxaspiro[4.5]decan-8-yl)benzonitrile
反応式
Br[C:2]1[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=1.C([Li])CCC.[CH2:15]1[O:25][C:18]2([CH2:23][CH2:22][CH2:21][CH2:20][C:19]2=O)[O:17][CH2:16]1.C1C[O:29]CC1.CCCCCC>>[CH2:15]1[O:25][C:18]2([CH2:23][CH2:22][C:21]([C:2]3[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[CH:4][CH:3]=3)([OH:29])[CH2:20][CH2:19]2)[O:17][CH2:16]1参加物
5
実験手順
4-Bromobenzonitrile was treated in THF-hexane with n-butyllithium at -100° C. Cyclohexanedione monoethylene ketal was added at -100° to give 70% yield of 11.
出典と根拠
- ORDレコード
- ord-83fccd9e25934bc7b89a55d5fce0a6c0
- 出典データセット
- uspto-grants-1991_12
- 特許番号
- US05077404
反応ノート
読み込み中…