関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 1-Iodododecane | HCID 20282 | — |
| 反応物 | Trilauryl phosphite | HCID 76495 | — |
| 反応物 | Benzenemethanamine,N-(phenylmethylene)-, N-oxide | HCID 305634 | — |
| 生成物 | Didodecyl P-[alpha-(N-Benzyl-N-dodecyloxyamino)benzyl]phosphonate | HCID 19883773 | 28% |
反応手順
A mixture of 5.0 g (23 mmol) of N-benzylidenebenzylamine N-oxide, 17.6 g (30 mmol) of tri-n-dodecyl phosphite and 29.6 g (100 mmol) of n-dodecyl iodide is heated at 70° C. for 24 hours. The reaction mixture is concentrated in vacuo and the residue is purified by HPLC (4:1 hexane:ethyl acetate eluent) followed by flash chromatography (methylene chloride eluent) to give 5.1 g (28% yield) of the title compound as a white solid melting at 38°-40° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05077329 |
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| 出典データセット | uspto-grants-1991_12 |
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| ORD ID | ord-e2ae07b1df9d489c892af2630f965bde |
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| 出典メモ | uspto-grants-1991_12 |
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