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Water → 3-amino-5-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 反応物 | 2-((Methoxy)(4-phenoxyphenyl)methylene)malononitrile | HCID 22347227 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-amino-5-(4-phenoxyphenyl)-1H-pyrazole-4-carbonitrile | HCID 22346784 | — |
反応手順
1,1-Dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene (22.5 g) and 1,1-dicyano-2-methoxy-2-(4-phenoxyphenyl)ethene oil (15 g) are treated with a solution of hydrazine hydrate (18 mL) in ethanol (25 mL) and heated on the steambath for 1 hour. Ethanol (15 mL) is added followed by water (10 mL). The precipitated solid is collected and washed with ethanol:water (4:1) and then dried in air to give 3-amino-4-cyano-5-(4-phenoxyphenyl)pyrazole as a pale orange solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732454B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-6c1b8747619e463ca1875ae0e21688f5 |
| 出典メモ | uspto-grants-2010_06 |