Sulfuric Acid → HCID 135837533、化合物
反応式
[Br:1][C:2]1[C:7]([CH2:8][CH3:9])=[C:6](Br)[N:5]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:3]=1.S(=O)(=O)(O)[OH:18]>O>[Br:1][C:2]1[N:3]=[C:4]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[NH:5][C:6](=[O:18])[C:7]=1[CH2:8][CH3:9]参加物
4
実験手順
To 8.29 g (26.1 mmol) of crude 4,6-dibromo-5-ethyl-2-phenylpyrimidine was added a mixture of 4 mL of water and 15 mL of concentrated sulfuric acid. The mixture was stirred for 18 h and poured onto 200 g of crushed ice. After the ice had melted the precipitate was collected by filtration and dried under vacuum to afford 7.21 g (99%) of crude 6-bromo-5-ethyl-2-phenyl-4(3H)-pyrimidinone. 1H-NMR (d6-DMSO) δ1.10(3H,t), 2.55(2H,q), 7.55(3H,m), 8.10(2H,m).
後処理
- filtrationwas collected by filtration
- customdried under vacuum
出典と根拠
- ORDレコード
- ord-3a8db97dc3fe436fabce1beaa06a8b12
- 出典データセット
- uspto-grants-1994_04
- 特許番号
- US05300477
反応ノート
読み込み中…