関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 6-Ethyl-2-phenylpyrimidin-4(1H)-one | HCID 135629822 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | 6-ethyl-5-iodo-2-phenyl-4(3H)-pyrimidinone | HCID 135837532 | 94.5% |
反応手順
A mixture of 8.18 g (40.9 mmol) of 6-ethyl-2-phenyl-4(3H)-pyrimidinone, 1.68 g (42.0 mmol) of sodium hydroxide, 10.42 g (41.0 mmol) of iodine and 50 mL of water was heated at 50° C. for 4 h. The mixture was cooled and filtered. The white solid collected was dried in a vacuum oven to leave 12.60 g (75%) of 6-ethyl-5-iodo-2-phenyl-4(3H)-pyrimidinone. 1H-NMR (d6-DMSO) δ1.25(3H,t), 2.85(2H,q), 7.50(3H,m), 8.15(2H,m).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05300477 |
|---|
| 出典データセット | uspto-grants-1994_04 |
|---|
| ORD ID | ord-4c9d4c3cc43f48239cf50ed33a1eee12 |
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| 出典メモ | uspto-grants-1994_04 |
|---|
