Methanol → 5-(4-Hydroxymethylbenzoyl)-3-thiophene sulfonamide
反応式
C([O:4][CH2:5][C:6]1[CH:22]=[CH:21][C:9]([C:10]([C:12]2[S:16][CH:15]=[C:14]([S:17]([NH2:20])(=[O:19])=[O:18])[CH:13]=2)=[O:11])=[CH:8][CH:7]=1)(=O)C.C([O-])([O-])=O.[K+].[K+].CO>C(OCC)(=O)C>[OH:4][CH2:5][C:6]1[CH:22]=[CH:21][C:9]([C:10]([C:12]2[S:16][CH:15]=[C:14]([S:17]([NH2:20])(=[O:19])=[O:18])[CH:13]=2)=[O:11])=[CH:8][CH:7]=1参加物
5
実験手順
14 mg (41.3 mmol) of 5-(4-acetoxymethylbenzoyl)-3-thiophene sulfonamide and 9 mg (61.8 mmol) of K2CO3 were added to 3 mL of methanol. After stirring at rt for 11 h the solution was diluted with ethyl acetate and washed with 1N HCl followed with water (2×) and brine. The solvent was removed under vacuum to afford 12.5 mg of 5-(4-hydroxymethylbenzoyl)-3-thiophene sulfonamide as a white solid.