O-Methyltyramine → HCID 18982108、化合物

HRID 1463269ノート

反応式

HRID 1463269 の反応式
[NH2:1][C:2]1[C:7]([N:8]=[O:9])=[C:6]([NH2:10])[N:5]=[C:4](SC)[N:3]=1.[CH3:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([CH2:19][CH2:20][NH2:21])=[CH:17][CH:16]=1>O>[NH2:1][C:2]1[C:7]([N:8]=[O:9])=[C:6]([NH2:10])[N:5]=[C:4]([NH:21][CH2:20][CH2:19][C:18]2[CH:22]=[CH:23][C:15]([O:14][CH3:13])=[CH:16][CH:17]=2)[N:3]=1

参加物

4

反応物 2

HCID 4657O-MethyltyramineHCID 3276844,6-Pyrimidinediamine, 2-(methylthio)-5-nitroso-

生成物 1

HCID 18982108HCID 18982108、化合物収率 84%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A mixture of 4,6-diamino-2-methylthio-5-nitrosopyrimidine (10 g, 5.4 mM), 4-methoxyphenethylamine (7.92 ml, 5.4 mM) and water (180 ml) was heated to reflux for one hour. After cooling the red solid was separated by filtration, washed with water, and dried. There was thus obtained 4,6-diamino-2-[2-(4-methoxyphenyl)ethyl]amino-5-nitrosopyrimidine (13.4 g, 84% yield). NMR: DMSO-d6 ; 2.7-2.85(m,2H, CH2 --CH2), 3.4-3.6(m, 2H, CH2 --NH), 3.7 (s, 3H, OCH3), 6.75-6.8(m,2H, aromatic-H), 7.05-7.25 (m, 2H, aromatic-H), 7.4-10.5 (m, 5H, NH2 ×2, NH), m/e [M+H[+ 289.

後処理

  1. temperaturewas heated
  2. temperatureto reflux for one hour
  3. temperatureAfter cooling the red solid
  4. customwas separated by filtration
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-ef8c6785a21945508157d766f6bbd8a3
出典データセット
uspto-grants-1994_04
特許番号
US05300509

反応ノート

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