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Benzenesulfinic acid → 2-(Benzenesulfonyl)-5-methoxyoxolane
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Benzenesulfinic acid | HCID 12057 | — |
| 反応物 | 2,5-Dimethoxytetrahydrofuran | HCID 79098 | — |
| 反応物 | Calcium Chloride | HCID 5284359 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-(Benzenesulfonyl)-5-methoxyoxolane | HCID 19930462 | 55% |
反応手順
2,5-Dimethoxytetrahydrofuran (17.1 ml, 0.13 M) was added dropwise to a stirred solution of benzenesulphinic acid (17.0 g, 0.12 M) in dry DCM (100ml) containing a suspension of powdered CaCl2 (1.0 g) at room temperature under argon. After 4 h, the solution was washed with water (2×50 ml), dried (Na2SO4) and evaporated. The product was crystallised (diethyl ether/hexane) to give 2-benzenesulphonyl-5-methoxytetrahydrofuran (15 9 g, 55%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05300524 |
| 出典データセット | uspto-grants-1994_04 |
| ORD ID | ord-6b5822870bbc4b8290e6f4a0e5d4a634 |
| 出典メモ | uspto-grants-1994_04 |