2,3,4,5-Tetrahydro-alpha-methyl-1-benzothiepine-8-methanol → 2,3,4,5-Tetrahydro-1-benzothiepin-8-yl methyl ketone

HRID 1463398ノート

反応式

HRID 1463398 の反応式
[CH3:1][CH:2]([C:4]1[CH:14]=[CH:13][C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][S:12][C:6]=2[CH:5]=1)[OH:3]>C(Cl)Cl.[O-2].[O-2].[Mn+4]>[CH3:1][C:2]([C:4]1[CH:14]=[CH:13][C:7]2[CH2:8][CH2:9][CH2:10][CH2:11][S:12][C:6]=2[CH:5]=1)=[O:3]

参加物

4

反応物 1

HCID 199354242,3,4,5-Tetrahydro-alpha-methyl-1-benzothiepine-8-methanol

生成物 1

HCID 199355372,3,4,5-Tetrahydro-1-benzothiepin-8-yl methyl ketone収率 94.5%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6344Dichloromethane溶媒

実験手順

7.80 g of 2,3,4,5-tetrahydro-α-methyl-1-benzothiepine-8-methanol were dissolved in 100 ml of methylene chloride, treated with 50 g of manganese dioxide (MnO2) and the reaction mixture was stirred overnight. Thereafter, the mixture was filtered over a filter aid and the solution was evaporated. There were obtained 7.30 g of 2,3,4,5-tetrahydro-1-benzothiepin-8-yl methyl ketone as a colorless oil.

後処理

  1. filtrationThereafter, the mixture was filtered over a filter aid
  2. customthe solution was evaporated

出典と根拠

ORDレコード
ord-8a7dddd06ea3426dbfb41c4050f52b90
出典データセット
uspto-grants-1994_04
特許番号
US05300522

反応ノート

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