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HRID 14635作成日：2026年10月25日

N-Methylbenzylamine → [4-(Benzyl-methyl-carbamoyl)-6,8-dimethoxy-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/14635

反応式

関与物質

役割名称HCID仕込み量
反応物N-MethylbenzylamineHCID 7669—
反応物1-(Tert-butoxycarbonylamino-methyl)-6,8-dimethoxy-isoquinoline-4-carboxylic acidHCID 59341098—
生成物[4-(Benzyl-methyl-carbamoyl)-6,8-dimethoxy-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl esterHCID 68614645—

反応手順

As described in example 1E, 100 mg of 1-(tert-butoxycarbonylamino-methyl)-6,8-dimethoxy-isoquinoline-4-carboxylic acid was coupled with benzyl-methyl-amine to give 100 mg of [4-(benzyl-methyl-carbamoyl)-6,8-dimethoxy-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester. MS: APCI (M+H) calc'd for C26H31N3O5+H 466.5; found 466.0.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07732446B1
出典データセットuspto-grants-2010_06
ORD IDord-c7d619561d7a436ab0e12556f2d648e7
出典メモuspto-grants-2010_06