Diethyl 3-trifluoromethylbenzylphosphonate → ((3-Trifluoromethyl)phenyl)methyl-phosphonic acid
反応式
[F:1][C:2]([F:19])([F:18])[C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[CH2:6][P:7](=[O:14])([O:11]CC)[O:8]CC>Cl.CCO>[F:18][C:2]([F:1])([F:19])[C:3]1[CH:4]=[C:5]([CH:15]=[CH:16][CH:17]=1)[CH2:6][P:7](=[O:8])([OH:11])[OH:14]参加物
4
実験手順
Diethyl 3-trifluoromethylbenzylphosphonate (3.0 g, 10.0 mmol) was dissolved in a mixture of 50 mL of conc hydrochloric acid and 1.5 mL of EtOH and was heated at reflux for 17 hours. After cooling the clear reaction mixture in an ice-water mixture, the white crystalline solid which formed was collected to give 2.05 g (84.3%) of the analytical product, mp=163°-164° C.; D.C.I.M.S.[MH+,241].
後処理
- temperaturewas heated
- temperatureat reflux for 17 hours
- customthe white crystalline solid which formed
- customwas collected
出典と根拠
- ORDレコード
- ord-bd957050fe8c4a5e8f4561d45493a7c1
- 出典データセット
- uspto-grants-1994_04
- 特許番号
- US05300687
反応ノート
読み込み中…