Diethyl {[3,5-bis(trifluoromethyl)phenyl]methyl}phosphonate → HCID 15818098、化合物
反応式
[F:1][C:2]([F:23])([F:22])[C:3]1[CH:4]=[C:5]([CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1)[CH2:6][P:7](=[O:14])([O:11]CC)[O:8]CC>Cl.C(O)C>[F:23][C:2]([F:1])([F:22])[C:3]1[CH:4]=[C:5]([CH:15]=[C:16]([C:18]([F:21])([F:19])[F:20])[CH:17]=1)[CH2:6][P:7](=[O:8])([OH:11])[OH:14]参加物
4
実験手順
Diethyl 3,5-bis(trifluoromethyl)benzylphosphonate (1.0 g, 2.7 mmol) in 15 mL of conc hydrochloric acid and 0.5 mL of ethanol was heated at reflux for 72 hours. The mixture was evaporated to an oily residue which crystallized upon standing to give 0.41 g of the product (49% yield) the as a white solid: mp. 206°-208° C.; D.C.I.M.S. [MH+, 309].
後処理
- temperatureat reflux for 72 hours
- customThe mixture was evaporated to an oily residue which
- customcrystallized
出典と根拠
- ORDレコード
- ord-ac9cd42d81d24031ba0d1272d16a818e
- 出典データセット
- uspto-grants-1994_04
- 特許番号
- US05300687
反応ノート
読み込み中…