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Sodium Hydroxide → 9,9-Bis(4-pyridinylmethyl)-2-fluorofluorene dihydrochloride
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 4-(Chloromethyl)pyridinium chloride | HCID 74570 | — |
| 反応物 | 2-Fluorofluorene | HCID 241132 | — |
| 触媒 | Benzyl triethylammonium chloride | HCID 66133 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 9,9-Bis(4-pyridinylmethyl)-2-fluorofluorene dihydrochloride | HCID 19090497 | — |
反応手順
The title compound was prepared following the method of Example 1 from 4.0 g (21.74 mmole) of 2-fluorofluorene, 8.92 g of 4-picolylchloride hydrochloride, 120 ml of toluene, 200 mg of benzyltriethylammonium chloride, and 20 ml of 50% sodium hydroxide by reaction at 22° for 17 hrs. The product was chromatographed (silica, CH2Cl2 /MeOH, 10:1) to yield 2.9 g which was recrystallized (ethanol-acetone) and converted to the dihydrochloride, m.p. >300°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05300642 |
| 出典データセット | uspto-grants-1994_04 |
| ORD ID | ord-d3b94428d93846a6b30aeb024e38248a |
| 出典メモ | uspto-grants-1994_04 |