3,5-Dimethylaniline → 3,5-diMethyl-cyclohexylaMine

HRID 1463835ノート

反応式

HRID 1463835 の反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([CH3:9])[CH:8]=1)[NH2:5]>[Ru]>[CH3:1][CH:2]1[CH2:8][CH:7]([CH3:9])[CH2:6][CH:4]([NH2:5])[CH2:3]1

参加物

3

反応物 1

HCID 79493,5-Dimethylaniline

生成物 1

HCID 146753743,5-diMethyl-cyclohexylaMine

試薬・触媒・溶媒 1

HCID 23950Ruthenium触媒

実験手順

N-cis, cis-3,5-Dimethylcyclohexyl-N-cyclopentyl amine is synthesized as shown in Scheme M. 3,5-Dimethylcyclohexyl amine is synthesized by catalytic hydrogenation of 3,5-dimethyl aniline for 7 to 24 hours. A suitable catalyst is 5% ruthenium on carbon. Hydrogenation pressure may change from 500 to 1500 psi and temperatures may range from 80° to 150°. N-cis cis-3,5-Dimethylcyclohexyl-N-cyclopentyl amine is formed by reductive amination of cyclpentanone with 3,5-dimethylcyclohexyl amine. The reductive amination may be carried out by hydrogenation using palladium on carbon as catalyst at pressures ranging from 15 to 90 psi. The temperature may range from room temperature to 50°. The reaction time is from 7 to 48 hours.

後処理

  1. customN-cis, cis-3,5-Dimethylcyclohexyl-N-cyclopentyl amine is synthesized
  2. custommay range from 80° to 150°

出典と根拠

ORDレコード
ord-5c3fca26dacd4245867dc83c1a5f047a
出典データセット
uspto-grants-1994_04
特許番号
US05302601

反応ノート

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