3-Oxo-4-aza-5-androstene-17beta-carboxylic acid → N-[1-(4-Methoxyphenyl)-1-methylethyl]-3-oxo-4-aza-androst-5-ene-17beta-carboxamide

HRID 1463948

反応式

HRID 1463948 の反応式
[O:1]=[C:2]1[CH2:19][CH2:18][C@@:17]2([CH3:20])[C:4](=[CH:5][CH2:6][C@@H:7]3[C@@H:16]2[CH2:15][CH2:14][C@@:12]2([CH3:13])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:21](O)=[O:22])[NH:3]1.[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([NH2:35])([CH3:34])[CH3:33])=[CH:28][CH:27]=1>>[CH3:24][O:25][C:26]1[CH:31]=[CH:30][C:29]([C:32]([NH:35][C:21]([C@H:11]2[CH2:10][CH2:9][C@H:8]3[C@H:7]4[C@H:16]([CH2:15][CH2:14][C@:12]23[CH3:13])[C@:17]2([CH3:20])[C:4]([NH:3][C:2](=[O:1])[CH2:19][CH2:18]2)=[CH:5][CH2:6]4)=[O:22])([CH3:33])[CH3:34])=[CH:28][CH:27]=1

参加物

3

反応物 2

HCID 4754473-Oxo-4-aza-5-androstene-17beta-carboxylic acidHCID 110082782-(4-Methoxyphenyl)propan-2-amine

生成物 1

HCID 67750660N-[1-(4-Methoxyphenyl)-1-methylethyl]-3-oxo-4-aza-androst-5-ene-17beta-carboxamide収率 65%

実験手順

The title compound was prepared in a yield of 65% in a similar manner to that described in Example 37 by reacting 3-oxo-4-azaandrost-5-ene-17β-carboxylic acid and 1-(4-methoxyphenyl)-1-methylethylamine.

出典と根拠

ORDレコード
ord-42321fbf4d07418db2e2f7fe63c57002
出典データセット
uspto-grants-1994_04
特許番号
US05302621

関連ノート

読み込み中…