Ethyl Acetate → HCID 19089105、化合物
反応式
[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[CH2:5][NH:6][NH2:7])[CH3:2].CO[C:13](=[CH2:16])[C:14]#[N:15].C(OCC)(=O)C>O>[CH2:1]([O:3][CH:4]([O:8][CH2:9][CH3:10])[CH2:5][N:6]1[C:14]([NH2:15])=[CH:13][CH:16]=[N:7]1)[CH3:2]参加物
5
実験手順
A mixture of hydrazinoacetaldehyde diethyl acetal (21 g) and methoxyacrylonitrile (11.8 g) in water (150 ml) was refluxed for 2 days. After the reaction mixture was cooled, to the mixture was added a mixture of water and ethyl acetate. The separated organic layer was washed with brine and dried over magnesium sulfate. The solvent was evaporated and the residue was subjected to column chromatography on silica gel using ethyl acetate as an eluent. Fractions containing the object compound were combined and evaporated to give 1-(2,2-diethoxyethyl)-5-aminopyrazole (5.45 g).
後処理
- temperaturewas refluxed for 2 days
- temperatureAfter the reaction mixture was cooled, to the mixture
- additionwas added
- washThe separated organic layer was washed with brine
- dry with materialdried over magnesium sulfate
- customThe solvent was evaporated
- additionFractions containing the object compound
- customevaporated
出典と根拠
- ORDレコード
- ord-18a4391a669a48c38274b7f29de18659
- 出典データセット
- uspto-grants-1994_04
- 特許番号
- US05302712
反応ノート
読み込み中…