化工社化工社 化学情報印刷レポート · 研究参考用
3-(Methylaminomethyl)pyridine → [6,8-Dimethoxy-4-(methyl-pyridin-3-ylmethyl-carbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-(Methylaminomethyl)pyridine | HCID 88393 | — |
| 反応物 | 1-(Tert-butoxycarbonylamino-methyl)-6,8-dimethoxy-isoquinoline-4-carboxylic acid | HCID 59341098 | — |
| 生成物 | [6,8-Dimethoxy-4-(methyl-pyridin-3-ylmethyl-carbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester | HCID 68614078 | — |
反応手順
As described in example 1E, 100 mg of 1-(tert-butoxycarbonylamino-methyl)-6,8-dimethoxy-isoquinoline-4-carboxylic acid was coupled with methyl-pyridin-3-ylmethyl-amine to give 98 mg of [6,8-dimethoxy-4-(methyl-pyridin-3-ylmethyl-carbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester. MS: APCI (M+H) calc'd for C20H22N4O3+H 367.2; found 367.2.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732446B1 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-d7db1c179afc4116a3c4ba73a6189407 |
| 出典メモ | uspto-grants-2010_06 |