Ethanol → 2-[1-(2-Hydroxyethyl)-2-imidazolidinyl-idene]-aminobiphenyl fumarate

HRID 1464036ノート

反応式

HRID 1464036 の反応式
I.[C:2]1([C:13]2C=CC=CC=2)[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[NH:8]C(=N)SC.[OH:19][CH2:20][CH2:21][NH:22][CH2:23][CH2:24][NH2:25].[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30].[CH2:34](O)[CH3:35]>CO>[C:26]([OH:33])(=[O:32])/[CH:27]=[CH:28]/[C:29]([OH:31])=[O:30].[OH:19][CH2:20][CH2:21][N:22]1[CH2:23][CH2:24][NH:25][C:13]1=[C:2]1[CH:3]([NH2:8])[CH:4]=[CH:5][CH:6]=[C:7]1[C:35]1[CH:34]=[CH:29][CH:28]=[CH:27][CH:26]=1

参加物

6

反応物 4

HCID 702EthanolHCID 8112N-(2-Hydroxyethyl)ethylenediamineHCID 444972Fumaric AcidHCID 178503972HCID 178503972、化合物

生成物 1

HCID 1317183872-[1-(2-Hydroxyethyl)-2-imidazolidinyl-idene]-aminobiphenyl fumarate

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 1-(2-biphenylyl)-2-methyl-2-thiopseudourea hydriodide (12 g prepared as described in Example 5) and N-(2-hydroxyethyl)ethylenediamine (10 g) in ethanol (145 ml) was heated under reflux for 165 hours. Removal of the solvent gave an oil which was dissolved in methanol and treated with fumaric acid to give 2-[1-(2-hydroxyethyl)-2-imidazolidinyl-idene]-aminobiphenyl fumarate (m.p. 165°-166° C.) which was recrystallised from a 1:2 mixture of methanol and ether.

後処理

  1. temperaturewas heated
  2. temperatureunder reflux for 165 hours
  3. customRemoval of the solvent
  4. customgave an oil which

出典と根拠

ORDレコード
ord-7676d414f45440c9b06f6714e0dd189a
出典データセット
uspto-grants-1994_04
特許番号
US05302720

反応ノート

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