[(4-Iodophenyl)sulfonyl]-2-pyridylamine → 2-Hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]ethenyl]benzoic acid

HRID 1464161ノート

反応式

HRID 1464161 の反応式
[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([OH:15])=[C:7]([CH:14]=1)[C:8]([O:10]C(C)C)=[O:9])=[CH2:2].I[C:17]1[CH:22]=[CH:21][C:20]([S:23]([NH:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)(=[O:25])=[O:24])=[CH:19][CH:18]=1>>[OH:15][C:6]1[CH:5]=[CH:4][C:3]([CH:1]=[CH:2][C:17]2[CH:18]=[CH:19][C:20]([S:23]([NH:26][C:27]3[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=3)(=[O:25])=[O:24])=[CH:21][CH:22]=2)=[CH:14][C:7]=1[C:8]([OH:10])=[O:9]

参加物

3

反応物 2

HCID 1143526[(4-Iodophenyl)sulfonyl]-2-pyridylamineHCID 19423367Isopropyl 5-ethenyl-2-hydroxybenzoate

生成物 1

HCID 543430162-Hydroxy-5-[2-[4-[(2-pyridinylamino)sulfonyl]phenyl]ethenyl]benzoic acid収率 40%

実験手順

Isopropyl 5-ethenyl-2-hydroxybenzoate was reacted with 4-iodo-N-(2-pyridinyl)benzenesulfonamide similarly to the procedure of Example 5c. After the reaction, the solvent was evaporated, toluene was added and the suspension filtered and washed with toluene. After drying on the filter and washing with water the material was hydrolyzed and precipitated similarly to the procedure of Example 3c. Yield 40%

後処理

  1. customAfter the reaction
  2. customthe solvent was evaporated
  3. additiontoluene was added
  4. filtrationthe suspension filtered
  5. washwashed with toluene
  6. customAfter drying on the
  7. filtrationfilter
  8. washwashing with water the material
  9. customprecipitated similarly to the procedure of Example 3c

出典と根拠

ORDレコード
ord-4cb10b7c04d846c792ef264b8e26d8bb
出典データセット
uspto-grants-1994_04
特許番号
US05302718

反応ノート

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