Acetic Anhydride → (S)-Benzyl (tetrahydro-2,5-dioxo-3-furyl)carbamate

HRID 1464209

反応式

HRID 1464209 の反応式
[CH2:1]([O:8][C:9]([NH:11][C@H:12]([C:17]([OH:19])=[O:18])[CH2:13][C:14]([OH:16])=O)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(OC(=O)C)(=O)C>C(O)(=O)C>[CH2:1]([O:8][C:9]([NH:11][C@@H:12]1[C:17](=[O:18])[O:19][C:14](=[O:16])[CH2:13]1)=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 2723942N-(Benzyloxycarbonyl)aspartic acid

生成物 1

HCID 11128682(S)-Benzyl (tetrahydro-2,5-dioxo-3-furyl)carbamate

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

For example, N-benzyloxycarbonyl-L-aspartic acid is dissolved in a large excess of acetic anhydride, the acetic acid formed by the reaction and the excess acetic anhydride are distilled off under reduced pressure and the effect of any acetic acid remaining in the residue is removed by the addition of an organic solvent to give N-benzyloxycarbonyl-L-aspartic anhydride [J. Am. Chem. Soc., 81, 167-173 (1959)].

後処理

  1. distillationthe excess acetic anhydride are distilled off under reduced pressure
  2. customthe effect of any acetic acid remaining in the residue is removed by the addition of an organic solvent

出典と根拠

ORDレコード
ord-0d00a997b1df4e23a14cef71c9b78832
出典データセット
uspto-grants-1994_04
特許番号
US05302743

関連ノート

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