3-Oxobutyronitrile → HCID 86747770、化合物

HRID 1464266

反応式

HRID 1464266 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH2:9])=[CH:4][N:3]=1.[C:10]([CH2:12][C:13](=O)[CH3:14])#[N:11]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][C:13]([CH3:14])=[CH:12][C:10]#[N:11])=[CH:4][N:3]=1

参加物

3

反応物 2

HCID 755793-OxobutyronitrileHCID 70209275-(Aminomethyl)-2-chloropyridine

生成物 1

HCID 86747770HCID 86747770、化合物収率 85%

実験手順

1.4 g of 2-chloro-5-pyridylmethylamine and 0.8 g of 1-cyano-2-propanone were mixed and the mixture was stirred at room temperature over night. The solvent was then distilled off and the residue was purified by column chromatography on silica gel to afford 1.7 g of compound No. 528. m.p. 95°-98° C.

後処理

  1. distillationThe solvent was then distilled off
  2. customthe residue was purified by column chromatography on silica gel

出典と根拠

ORDレコード
ord-0787945b338f4211b0c021907cfd5215
出典データセット
uspto-grants-1994_04
特許番号
US05304566

関連ノート

読み込み中…