Ethanimidic acid, ethyl ester, hydrochloride (1:1) → N-((6-chloropyridin-3-yl)methyl)-N-methylethanimidamide hydrochloride
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][CH3:10])=[CH:4][N:3]=1.Cl.[C:12](=[NH:17])(OCC)[CH3:13]>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]([CH3:10])[C:12](=[NH:17])[CH3:13])=[CH:4][N:3]=1参加物
4
実験手順
To 40 ml of ethanol was added 5.1 g of N-(2-chloro-5-pyridylmethyl)-N-Methylamine and then 4 g of ethyl acetimidate hydrochloride at 0° C. After stirring for an hour, the reaction mixture was allowed to warm to room temperature and stirred over night. The solvent was then distilled off. The obtained white residue was washed with diethyl ether to afford 7.3 g of the title compound m.p. 192°-197° C.
後処理
- customat 0° C
- stirringstirred over night
- distillationThe solvent was then distilled off
- washThe obtained white residue was washed with diethyl ether
出典と根拠
- ORDレコード
- ord-f2fdee4c7308435e9c9b9449b0ee2875
- 出典データセット
- uspto-grants-1994_04
- 特許番号
- US05304566
反応ノート
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