Acetic Anhydride → 2-acetoxymethyl-5-methoxy-N-(3-pyridylmethyl)benzamide

HRID 1464299

反応式

HRID 1464299 の反応式
[OH:1][CH2:2][C:3]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:4]=1[C:5]([NH:7][CH2:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[O:6].C(N(CC)CC)C.[C:28](OC(=O)C)(=[O:30])[CH3:29]>C(Cl)Cl>[C:28]([O:1][CH2:2][C:3]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][C:4]=1[C:5]([NH:7][CH2:8][C:9]1[CH:10]=[N:11][CH:12]=[CH:13][CH:14]=1)=[O:6])(=[O:30])[CH3:29]

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 200820052-hydroxymethyl-5-methoxy-N-(3-pyridylmethyl)benzamide

生成物 1

HCID 200820032-acetoxymethyl-5-methoxy-N-(3-pyridylmethyl)benzamide収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 710 mg of 2-hydroxymethyl-5-methoxy-N-(3-pyridylmethyl) benzamide and 317 mg of triethylamine in 10 ml of methylene chloride was chilled at 0° C., mixed with 320 mg of acetic anhydride and stirred at room temperature for 15 hours. The reaction mixture was washed with water and saturated brine in order. The organic layer was dried over anhydrous magnesium sulfate and concentrated in vacuo to give 820 mg of the titled compound.

後処理

  1. washThe reaction mixture was washed with water and saturated brine in order
  2. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-417f44e2e8774e5bb426b3d89b2514ab
出典データセット
uspto-grants-1994_04
特許番号
US05304556

関連ノート

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