Ethanol → Imidazole,2-nitro-1-(3-methoxy-2-fluoro)propyl-
反応式
O[CH:2]([CH2:12][O:13][CH3:14])[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[N+:9]([O-:11])=[O:10].CCN(S(F)(F)[F:21])CC.C(O)C>O1CCOCC1>[F:21][CH:2]([CH2:12][O:13][CH3:14])[CH2:3][N:4]1[CH:8]=[CH:7][N:6]=[C:5]1[N+:9]([O-:11])=[O:10]参加物
5
実験手順
To a solution of 914 mg (4.54 mmol) of 1-(2'-hydroxy-3'-methoxypropyl)-2-nitroimidazole in 5.0 ml of dry dioxane, 1.00 g (6.20 mmol) of DAST was dropwise added with cooling by ice and then reacted for 2 hours at room temperature with stirring. After reaction, to the solution, 5.0 ml of ethanol was added to decompose excess DAST. The solution was then concentrated and subjected to isolation and purification by silica gel column chromatography to give 480 mg of 1-(2-'-fluoro-3'-methoxypropyl)-2-nitroimidazole.
後処理
- temperaturewith cooling by ice
- customreacted for 2 hours at room temperature
- customAfter reaction
- concentrationThe solution was then concentrated
- customsubjected to isolation and purification by silica gel column chromatography
出典と根拠
- ORDレコード
- ord-2adec24f4e3b40cc9faa6cf0182a4ecc
- 出典データセット
- uspto-grants-1994_04
- 特許番号
- US05304654
反応ノート
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