Ammonium Hydroxide → 2-Amino-pyrazino[2,3-b]pyridine

HRID 1464632ノート

反応式

HRID 1464632 の反応式
Cl[C:2]1[CH:11]=[N:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[N:3]=1.[OH-].[NH4+:13]>C(O)(C)C>[NH2:13][C:2]1[CH:11]=[N:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[N:3]=1

参加物

4

反応物 2

HCID 14923Ammonium HydroxideHCID 218561722-Chloropyrido[2,3-b]pyrazine

生成物 1

HCID 190871102-Amino-pyrazino[2,3-b]pyridine

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

反応条件

温度
115 °C

実験手順

A mixture of 2-chloro-pyrazino[2,3-b]pyridine (3.35g), isopropanol (20 mL) and concentrated ammonium hydroxide (50 mL) was heated at 115° C. for 17 h in a sealed tube. The tube was cooled and the product was collected and recrystallized from ethanol to afford 2-amino-pyrazino[2,3-b]pyridine as a yellow solid.

後処理

  1. temperatureThe tube was cooled
  2. customthe product was collected
  3. customrecrystallized from ethanol

出典と根拠

ORDレコード
ord-1bcb73e2563b4b7ebaf84d2454ea9024
出典データセット
uspto-grants-1994_04
特許番号
US05306819

反応ノート

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