Hydrogen chloride-ethyl acetate → 4-Cyclobutoxy-6-(piperazin-1-yl)pyrimidine dihydrochloride

HRID 1464955ノート

反応式

HRID 1464955 の反応式
[CH:1]1([O:5][C:6]2[N:11]=[CH:10][N:9]=[C:8]([N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[CH:7]=2)[CH2:4][CH2:3][CH2:2]1.[ClH:25].CCOC(C)=O>CCOC(C)=O>[ClH:25].[ClH:25].[CH:1]1([O:5][C:6]2[CH:7]=[C:8]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[N:9]=[CH:10][N:11]=2)[CH2:4][CH2:3][CH2:2]1

参加物

4

反応物 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66747845Tert-butyl 4-(6-cyclobutoxypyrimidin-4-yl)piperazine-1-carboxylate

生成物 1

HCID 667473944-Cyclobutoxy-6-(piperazin-1-yl)pyrimidine dihydrochloride

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of tert-butyl 4-(6-cyclobutoxypyrimidin-4-yl)piperazine-1-carboxylate (687 mg, 2.06 mmol) and 4 M HCl-EtOAc (30 ml) were stirred at rt for 2 h. Then EtOAc was added, and the solvent was removed in vacuo. The residue was suspended in EtOAc, and the white precipitate was collected by filtration to give 525 mg (quant) of the title compound as a white solid. The compound was used for the next step without further purification.

後処理

  1. customthe solvent was removed in vacuo
  2. filtrationthe white precipitate was collected by filtration

出典と根拠

ORDレコード
ord-a71444613f0f426181b450ba87fc8be5
出典データセット
uspto-grants-2015_04
特許番号
US08999974B2

反応ノート

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