Ammonia → 7-Bromothieno[3,2-d]pyrimidin-4-amine
反応式
[Br:1][C:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10](Cl)[C:5]=2[S:4][CH:3]=1.[NH3:12]>C(O)(C)C>[Br:1][C:2]1[C:6]2[N:7]=[CH:8][N:9]=[C:10]([NH2:12])[C:5]=2[S:4][CH:3]=1参加物
4
反応条件
- 温度
- 100 °C
実験手順
7-Bromo-4-chlorothieno[3,2-d]pyrimidine (5 g, 20.17 mmol) obtained in Step 3 of Preparation Example 1 and 2.0M NH3 dissolved in isopropanol solution (50 mL) were added to a sealed reaction vessel and stirred at 100° C. for 12 hours. The reaction mixture was cooled to room temperature and filtered to obtain a solid. The solid was washed with water and dried with N2 gas to obtain the title compound (3.8 g, 83%) without further purification.
後処理
- additionwere added to a sealed reaction vessel
- temperatureThe reaction mixture was cooled to room temperature
- filtrationfiltered
- customto obtain a solid
- washThe solid was washed with water
- dry with materialdried with N2 gas
出典と根拠
- ORDレコード
- ord-ec173c7db495431682d8f1447eedaf48
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US08999973B2
反応ノート
読み込み中…