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Lithium Hydroxide → 1-(tert-Butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinoline-4-carboxylic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Lithium Hydroxide | HCID 3939 | — |
| 反応物 | 1-(Tert-butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinoline-4-carboxylic acid ethyl ester | HCID 59341107 | — |
| 生成物 | 1-(tert-Butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinoline-4-carboxylic acid | HCID 59341071 | — |
反応手順
A sample of 1-(tert-butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinoline-4-carboxylic acid ethyl ester was hydrolyzed with 2 eq of LiOH as described in Example 1D to give 1-(tert-Butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinoline-4-carboxylic acid: 1H NMR (DMSO-d6) δ 1.37 (s, 9H), 3.90 (s, 3H), 3.93 (s, 3H), 4.74 (d, 2H), 7.33-7.36 (m, 1H), 7.61 (s, 1H), 8.37 (s, 1H), 8.82 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07732446B1 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-1405563673be41e0a51a0c6f0ff7210d |
| 出典メモ | uspto-grants-2010_06 |