Potassium Hydroxide → HCID 25232990、化合物
反応式
[CH3:1][N:2]1[CH2:15][CH2:14][C:5]2[NH:6][C:7]3[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][C:12]=3[C:4]=2[CH2:3]1.[F:16][C:17]1[CH:18]=[N:19][CH:20]=[C:21]([CH:23]=[CH2:24])[CH:22]=1.[OH-].[K+]>CN1C(=O)CCC1>[F:16][C:17]1[CH:22]=[C:21]([CH2:23][CH2:24][N:6]2[C:7]3[CH:8]=[CH:9][C:10]([CH3:13])=[CH:11][C:12]=3[C:4]3[CH2:3][N:2]([CH3:1])[CH2:15][CH2:14][C:5]2=3)[CH:20]=[N:19][CH:18]=1参加物
5
実験手順
The title compound is prepared from a mixture of 2,3,4,5-tetrahydro-2,8-dimethyl-1H-pyrido[4,3-b]indole, 3-fluoro-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100 deg C. The product obtained is isolated by preparative HPLC.
後処理
- customranging between 25 deg C
- customto 100 deg C
- customThe product obtained
- customis isolated by preparative HPLC
出典と根拠
- ORDレコード
- ord-0896f42ad5d74aa8a36b3bb3a3891373
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US08999978B2
反応ノート
読み込み中…