Thiourea → HCID 43141115、化合物

HRID 1465663ノート

反応式

HRID 1465663 の反応式
Cl[CH2:2][C:3]([C:5]1[C:10]([F:11])=[CH:9][C:8]([F:12])=[CH:7][C:6]=1[F:13])=O.[NH2:14][C:15]([NH2:17])=[S:16]>CCO>[F:13][C:6]1[CH:7]=[C:8]([F:12])[CH:9]=[C:10]([F:11])[C:5]=1[C:3]1[N:14]=[C:15]([NH2:17])[S:16][CH:2]=1

参加物

4

反応物 2

HCID 2723790ThioureaHCID 185218922-Chloro-1-(2,4,6-trifluorophenyl)ethan-1-one

生成物 1

HCID 43141115HCID 43141115、化合物収率 97%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 2-chloro-1-(2,4,6-trifluorophenyl)ethanone (9.04 g, 43.5 mmol) and thiourea (3.51 g, 46.1 mmol) in 95% EtOH (50 mL) was heated at reflux overnight. The solution was concentrated and mixed with water (100 mL) and saturated aqueous Na2CO3 (5.0 mL). The solids were filtered and dried under vacuum to give 4-(2,4,6-trifluorophenyl)thiazol-2-amine (9.71 g) as pink-white solids in 97% yield: 1H NMR (500 MHz, DMSO-d6) δ 7.26-7.22 (m, 2 H), 7.09 (s, 2 H), 6.77 (s, 1 H).

後処理

  1. temperaturewas heated
  2. temperatureat reflux overnight
  3. concentrationThe solution was concentrated
  4. additionmixed with water (100 mL) and saturated aqueous Na2CO3 (5.0 mL)
  5. filtrationThe solids were filtered
  6. customdried under vacuum

出典と根拠

ORDレコード
ord-e48bd4a6b4bf497798508c3ee0d0bfd3
出典データセット
uspto-grants-2015_04
特許番号
US08999983B2

反応ノート

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