6-Chloro-2-iodothieno[2,3-b]pyridine → 6-Chlorothieno[2,3-b]pyridine-2-carbonitrile
反応式
[Cl:1][C:2]1[N:7]=[C:6]2[S:8][C:9](I)=[CH:10][C:5]2=[CH:4][CH:3]=1.[Cu][C:13]#[N:14]>CN(C=O)C>[Cl:1][C:2]1[N:7]=[C:6]2[S:8][C:9]([C:13]#[N:14])=[CH:10][C:5]2=[CH:4][CH:3]=1参加物
4
反応条件
- 温度
- 130 °C
実験手順
A mixture of 6-Chloro-2-iodothieno[2,3-b]pyridine (80 mg, 0.27 mmol) and Copper (I) Cyanide (36 mg, 0.41 mmol) in DMF (3 mL) was heated to 130° C. for 16 hrs. LC showed formation of the title product. The crude reaction was adsorbed onto silica gel, and purified by flash chromatography to obtain the title product. LC-MS (IE, m/z): 195 [M+1]+.
出典と根拠
- ORDレコード
- ord-e01035dc66a94ca280f2082a95818aac
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US08999991B2
反応ノート
読み込み中…