Methanol → 2-(Methyloxy)-4-(2-oxoethyl)benzonitrile
反応式
[CH3:1][O:2][C:3]1[CH:10]=[C:9]([CH2:11][CH:12]=C)[CH:8]=[CH:7][C:4]=1[C:5]#[N:6].CSC.C[OH:18]>>[CH3:1][O:2][C:3]1[CH:10]=[C:9]([CH2:11][CH:12]=[O:18])[CH:8]=[CH:7][C:4]=1[C:5]#[N:6]参加物
4
実験手順
To a 25 mL flask containing a stir bar was added compound 2-(methyloxy)-4-prop-2-en-1-ylbenzonitrile (0.15 g, 0.87 mmol) and MeOH (8 mL). The flask was placed in a cold bath of −78° C. Ozone was bubbled through the flask for about 10 min. followed by addition of dimethyl sulfide (1.5 mL, 24 mmol). The flask was taken out of the cold bath and stirred at room temperature for 1 h; LC indicated completion of the reaction. The reaction mixture was concentrated to dryness to give 2-(methyloxy)-4-(2-oxoethyl)benzonitrile. LC-MS (IE, m/z): 176 [M+1]+.
後処理
- additionTo a 25 mL flask containing a stir bar
- customThe flask was placed in a cold bath of −78° C
- customOzone was bubbled through the flask for about 10 min.
- customcompletion of the reaction
- concentrationThe reaction mixture was concentrated to dryness
出典と根拠
- ORDレコード
- ord-d762e888fc9247a58be9702fee0d6094
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US08999991B2
反応ノート
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