Boron tribromide → 5-Formyl-5,6,7,8-tetrahydronaphthalene-1-carbonitrile
反応式
C[O:2][CH:3]=[C:4]1[CH2:13][CH2:12][CH2:11][C:10]2[C:9]([C:14]#[N:15])=[CH:8][CH:7]=[CH:6][C:5]1=2.B(Br)(Br)Br>C(Cl)Cl>[CH:3]([CH:4]1[CH2:13][CH2:12][CH2:11][C:10]2[C:9]([C:14]#[N:15])=[CH:8][CH:7]=[CH:6][C:5]1=2)=[O:2]参加物
4
実験手順
A solution of 5-(methoxymethylene)-5,6,7,8-tetrahydronaphthalene-1-carbonitrile (320 mg, 1.61 mmol) in DCM (7 mL) was added BBr3 (1.2 g, 4.8 mmol) dropwise at −78° C. under N2, then the mixture was stirred at this temperature for 3 h. It was poured into ice-saturated NaHCO3 solution, and extracted with DCM. The organic layer was washed with brine and dried over Na2SO4. The solvent was removed in vacuo to give crude title compound, which was used for next step.
後処理
- additionIt was poured into ice-saturated NaHCO3 solution
- extractionextracted with DCM
- washThe organic layer was washed with brine
- dry with materialdried over Na2SO4
- customThe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-4c5b7f83f37a49f7a01309ba088307a8
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US08999990B2
反応ノート
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