Acetic Anhydride → N-(1-(tert-Butyl)-3-methyl-1H-pyrazol-5-yl)acetamide

HRID 1466209

反応式

HRID 1466209 の反応式
[C:1]([N:5]1[C:9]([NH2:10])=[CH:8][C:7]([CH3:11])=[N:6]1)([CH3:4])([CH3:3])[CH3:2].[C:12](OC(=O)C)(=[O:14])[CH3:13]>>[C:1]([N:5]1[C:9]([NH:10][C:12](=[O:14])[CH3:13])=[CH:8][C:7]([CH3:11])=[N:6]1)([CH3:4])([CH3:3])[CH3:2]

参加物

3

反応物 2

HCID 7918Acetic AnhydrideHCID 7372001-tert-Butyl-3-methyl-1H-pyrazol-5-amine

生成物 1

HCID 6621900N-(1-(tert-Butyl)-3-methyl-1H-pyrazol-5-yl)acetamide

実験手順

To 1-(tert-butyl)-3-methyl-1H-pyrazol-5-amine (110 g, 0.71 mol), acetic anhydride (73 ml, 0.71 mol) was added dropwise with stirring. The reaction mixture was stirred for 1-2 h at 20-35° C. Thereafter the reaction mixture was washed with excess of hexane and filtered to obtain the title compound as a yellow solid. MP: 118-120° C.

後処理

  1. stirringThe reaction mixture was stirred for 1-2 h at 20-35° C
  2. washThereafter the reaction mixture was washed with excess of hexane
  3. filtrationfiltered

出典と根拠

ORDレコード
ord-a75fe8f3cd8a438e986c2deec58880fe
出典データセット
uspto-grants-2015_04
特許番号
US09000007B2

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