Acetic Anhydride → N-(4-Phenoxyphenyl)acetamide

HRID 1466469ノート

反応式

HRID 1466469 の反応式
[O:1]([C:8]1[CH:14]=[CH:13][C:11]([NH2:12])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(CC)CC)C.[C:22](OC(=O)C)(=[O:24])[CH3:23]>ClCCl>[O:1]([C:8]1[CH:9]=[CH:10][C:11]([NH:12][C:22](=[O:24])[CH3:23])=[CH:13][CH:14]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

参加物

5

反応物 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 8764(4-Aminophenoxy)benzene

生成物 1

HCID 80579N-(4-Phenoxyphenyl)acetamide収率 89.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Commercial available 4-phenoxy-aniline (4.16 g, 20.8 mmol) was dissolved in dichloromethane (100 mL), and triethylamine (3.05 g, 31.1 mmol) and acetic anhydride (2.22 g, 20.8 mmol) were added in drops. The mixture was stirred for 1 h at 0° C. to room temperature. After completion of the reaction, the mixture was filtered using dichloromethane and crystallized to give the title compound (4.50 g, 18.6 mmol)

後処理

  1. customAfter completion of the reaction
  2. filtrationthe mixture was filtered
  3. customcrystallized

出典と根拠

ORDレコード
ord-137788353f0e4acfaa18cbfa46c1847f
出典データセット
uspto-grants-2015_04
特許番号
US09000028B2

反応ノート

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