Methylamine → 4-(5-Chloro-2-phenyl-1H-indol-7-yl)amino-cyclohexanecarboxylic acid methylamide

反応式

[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([NH:11][CH:12]3[CH2:17][CH2:16][CH:15]([C:18](O)=[O:19])[CH2:14][CH2:13]3)[CH:10]=1)[NH:7][C:6]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)=[CH:5]2.[CH3:27][NH2:28]>>[CH3:27][NH:28][C:18]([CH:15]1[CH2:16][CH2:17][CH:12]([NH:11][C:9]2[CH:10]=[C:2]([Cl:1])[CH:3]=[C:4]3[C:8]=2[NH:7][C:6]([C:21]2[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=2)=[CH:5]3)[CH2:13][CH2:14]1)=[O:19]

参加物

反応物 2

HCID 6329Methylamine

HCID 68476533HCID 68476533、化合物

生成物 1

HCID 684741054-(5-Chloro-2-phenyl-1H-indol-7-yl)amino-cyclohexanecarboxylic acid methylamide

実験手順

4-(5-Chloro-2-phenyl-1H-indol-7-yl)amino-cyclohexane-1-carboxylic acid prepared in Example 102 and methylamine (HCl salt) were reacted according to the same procedure as Example 92 to give the title compound.

出典と根拠

ORDレコード: ord-e209704ab6c04a9ab96c9d4146ea303c
出典データセット: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09000028B2

反応ノート

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