Hydrazine → ethyl 5-(5-chloro-2-methoxyphenyl)-1H-pyrazole-4-carboxylate

HRID 1466552ノート

反応式

HRID 1466552 の反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:20][CH3:21])=[C:6]([CH:19]=1)[C:7]([C:9](=[CH:15][N:16](C)C)[C:10]([O:12][CH2:13][CH3:14])=[O:11])=O.[NH2:22]N>C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:20][CH3:21])=[C:6]([C:7]2[NH:22][N:16]=[CH:15][C:9]=2[C:10]([O:12][CH2:13][CH3:14])=[O:11])[CH:19]=1

参加物

4

反応物 2

HCID 9321HydrazineHCID 66847508Ethyl 2-(5-chloro-2-methoxybenzoyl)-3-(dimethylamino)acrylate

生成物 1

HCID 66677632ethyl 5-(5-chloro-2-methoxyphenyl)-1H-pyrazole-4-carboxylate

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A solution of ethyl 2-(5-chloro-2-methoxybenzoyl)-3-(dimethylamino)acrylate (2.49 g, 8.00 mmol, 1 eq) and hydrazine (0.40 mL, 13 mmol, 1.6 eq) in 20 mL ethanol was heated at 70° C. for 2 hours. Solvent and excess hydrazine were then evaporated to provide ethyl 5-(5-chloro-2-methoxyphenyl)-1H-pyrazole-4-carboxylate, which was used without further purification. LCMS (ESI) m+H=281.3.

後処理

  1. customSolvent and excess hydrazine were then evaporated

出典と根拠

ORDレコード
ord-45ea6379dec34a02966fbbd6fd6f092c
出典データセット
uspto-grants-2015_04
特許番号
US08999998B2

反応ノート

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