3-Hydroxyisovaleric acid → N-((5-chloro-2-methoxyphenyl)(cyano)methyl)-3-hydroxy-3-methylbutanamide

反応式

NC(C1C=C(Cl)C=CC=1OC)C#N.OC(C)(C)CC(O)=O.[Si]([O:29][C:30]([CH3:48])([CH3:47])[CH2:31][C:32]([NH:34][CH:35]([C:38]1[CH:43]=[C:42]([Cl:44])[CH:41]=[CH:40][C:39]=1[O:45][CH3:46])[C:36]#[N:37])=[O:33])(C(C)(C)C)(C)C>>[Cl:44][C:42]1[CH:41]=[CH:40][C:39]([O:45][CH3:46])=[C:38]([CH:35]([C:36]#[N:37])[NH:34][C:32](=[O:33])[CH2:31][C:30]([OH:29])([CH3:48])[CH3:47])[CH:43]=1

参加物

反応物 3

HCID 693623-Hydroxyisovaleric acid

HCID 66847023Amino-(5-chloro-2-methoxy-phenyl)-acetonitrile

HCID 668471763-(tert-butyldimethylsilyloxy)-N-((5-chloro-2-methoxyphenyl)(cyano)methyl)-3-methylbutanamide

生成物 1

HCID 66847322N-((5-chloro-2-methoxyphenyl)(cyano)methyl)-3-hydroxy-3-methylbutanamide

実験手順

Using amino-(5-chloro-2-methoxy-phenyl)-acetonitrile and 3-hydroxy-3-methyl-butyric acid, the title compound was synthesized following the synthetic procedures described for 3-(tert-butyldimethylsilyloxy)-N-((5-chloro-2-methoxyphenyl)(cyano)methyl)-3-methylbutanamide to give N-((5-chloro-2-methoxyphenyl)(cyano)methyl)-3-hydroxy-3-methylbutanamide. LCMS (ESI) m+H=297.1.