Ethanol → Ethyl 3-bromo-4-methoxybenzoate

HRID 1466813ノート

反応式

HRID 1466813 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=[O:6].OS(O)(=O)=O.[CH3:18][CH2:19]O>>[CH2:18]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:2]([Br:1])[CH:3]=1)[CH3:19]

参加物

4

反応物 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 668363-Bromo-4-methoxybenzoic acid

生成物 1

HCID 23062539Ethyl 3-bromo-4-methoxybenzoate

実験手順

3-Bromo-4-methoxy-benzoic acid (2.5 g, 11.6 mmol) was dissolved in EtOH (20 mL) and conc. H2SO4 (1 mL) was added. The reaction was heated to reflux overnight then submitted to standard aqueous workup. The residue was purified by silica gel chromatography (0-50% EtOAc in hexanes) to yield the title compound.

後処理

  1. temperatureThe reaction was heated
  2. temperatureto reflux overnight
  3. customThe residue was purified by silica gel chromatography (0-50% EtOAc in hexanes)

出典と根拠

ORDレコード
ord-93cd1783997c4f829e87d3da859135cd
出典データセット
uspto-grants-2015_04
特許番号
US09000025B2

反応ノート

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