Ethanol → HCID 66765121、化合物
反応式
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]([F:15])([F:14])[F:13])=[C:6]([CH2:8][C:9]([OH:11])=[O:10])[CH:7]=1.OS(O)(=O)=O.[CH3:21][CH2:22]O>>[CH2:21]([O:10][C:9](=[O:11])[CH2:8][C:6]1[CH:7]=[C:2]([Cl:1])[CH:3]=[CH:4][C:5]=1[C:12]([F:13])([F:14])[F:15])[CH3:22]参加物
4
実験手順
To a stirred solution of (5-Chloro-2-trifluoromethyl-phenyl)-acetic acid (10.0 g, 47.2 mmol) in absolute EtOH (300 mL) at room temperature was added concentrated H2SO4 (4 mL) and the mixture was warmed to reflux. After 4 hrs, the reaction was cooled to room temperature, evaporated under reduced pressure, diluted with DCM (500 mL) and stirred over solid K2CO3. After 1 hr, the resulting mixture was filtered and concentrated to dryness to afford the title compound.
後処理
- temperaturethe mixture was warmed to reflux
- customevaporated under reduced pressure
- additiondiluted with DCM (500 mL)
- waitAfter 1 hr
- filtrationthe resulting mixture was filtered
- concentrationconcentrated to dryness
出典と根拠
- ORDレコード
- ord-56bda05d78604df3bb1491a20877192c
- 出典データセット
- uspto-grants-2015_04
- 特許番号
- US09000025B2
反応ノート
読み込み中…