2-Amino-6-fluorobenzonitrile → N-(4-((3-Amino-2-cyanophenoxy)methyl)cyclohexyl)isonicotinamide

反応式

[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([NH:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH2:5][CH2:4]1.[NH2:18][C:19]1[CH:26]=[CH:25][CH:24]=[C:23](F)[C:20]=1[C:21]#[N:22]>>[NH2:18][C:19]1[C:20]([C:21]#[N:22])=[C:23]([CH:24]=[CH:25][CH:26]=1)[O:1][CH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([NH:9][C:10](=[O:17])[C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[CH2:5][CH2:4]1

参加物

反応物 2

HCID 5226592-Amino-6-fluorobenzonitrile

HCID 66746905N-(4-(Hydroxymethyl)cyclohexyl)isonicotinamide

生成物 1

HCID 66745739N-(4-((3-Amino-2-cyanophenoxy)methyl)cyclohexyl)isonicotinamide

実験手順

Prepared as in Example 22b from N-(4-(Hydroxymethyl)cyclohexyl)isonicotinamide (Example 108c) and 2-amino-6-fluorobenzonitrile as a colorless oil (6%). MS 351 (MH+).

出典と根拠

ORDレコード: ord-9543a371dd544da7bde852354b4b45d0
出典データセット: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US09000054B2

反応ノート

読み込み中…