Hydrochloric Acid → 2-(1-Aminomethyl-6,7-dimethoxy-isoquinolin-4-ylamino)thiazole-4-carboxylic acid ethyl ester hydrochloride salt

HRID 14672

反応式

HRID 14672 の反応式
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=3)[C:15]([CH2:26][NH:27]C(OC(C)(C)C)=O)=[N:14][CH:13]=2)[S:9][CH:10]=1)=[O:5])[CH3:2].[ClH:35]>C(Cl)Cl.O1CCOCC1>[ClH:35].[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([NH:11][C:12]2[C:21]3[C:16](=[CH:17][C:18]([O:24][CH3:25])=[C:19]([O:22][CH3:23])[CH:20]=3)[C:15]([CH2:26][NH2:27])=[N:14][CH:13]=2)[S:9][CH:10]=1)=[O:5])[CH3:2]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 593411022-[1-(Tert-butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinolin-4-ylamino]thiazole-4-carboxylic acid ethyl ester

生成物 1

HCID 867611282-(1-Aminomethyl-6,7-dimethoxy-isoquinolin-4-ylamino)thiazole-4-carboxylic acid ethyl ester hydrochloride salt収率 93%

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒

実験手順

2-[1-(tert-Butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinolin-4-ylamino]-thiazole-4-carboxylic acid ethyl ester (40 mg, 0.0818 mmol) in CH2Cl2 (1.0 mL) was treated with a 4.0 M HCl solution in dioxane (0.21 mL) at room temperature. After the reaction mixture was stirred at room temperature for 15 h, the suspension was filtered. The yellow solid was dried in vacuo to give 2-(1-aminomethyl-6,7-dimethoxy-isoquinolin-4-ylamino)thiazole-4-carboxylic acid ethyl ester hydrochloride salt (32.3 mg; 93%). 1H-NMR (D2O): δ, 8.81 (s, 1H), 7.46 (s, 1H), 7.18 (s, 1H), 7.13 (s, 1H), 4.63 (s, 2H), 4.14 (q, 2H, J=7.1 Hz), 3.86 (s, 3H), 3.83 (s, 3H), 1.20 (t, 3H, J=7.3 Hz); MS: calculated for C18H21N4O4S (M−Cl) 389.0; found: 389.0.

後処理

  1. filtrationthe suspension was filtered
  2. customThe yellow solid was dried in vacuo

出典と根拠

ORDレコード
ord-d5a92311e4554d24ad3325e95119763c
出典データセット
uspto-grants-2010_06
特許番号
US07732446B1

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